What is NMN and why is it vital to your health?
What is NMN and why is it vital to your health?
What is NMN?
Why is NMN so important?
NAD+ helps carry out the chemical reactions in your cells that turn food into energy (a process called metabolism).
This energy is used by your body for hundreds of processes you don’t even notice, like repairing damage, fighting infection, combating inflammation, fueling brain function, even warding off the effects of aging itself. There is almost no biological process that doesn’t need NAD+1.
The building blocks of good health
Your cells control how you move, how you feel, how you think and how you age. The more you can do to ensure that your cells are in good working order, the better your short and long-term health is.
That’s why it’s important to keep your body’s supplies of NMN and NAD+ plentiful – to power the hundreds of processes your cells perform which enable you to survive and thrive.
NAD+ declines with age
The more your NAD+ pool is depleted, the less fuel there is to support the hundreds of processes which keep your body running. Declining NAD+ is one of the main drivers of the development of mitochondrial dysfunction (which causes many of the negative associations of aging like lost energy, poor sleep and reduced function of key organs and systems) and age-related diseases3, which all take a serious toll on your health.
Where do you get NMN from?
How to boost NAD+ naturally with NMN
Supplementing with NMN delivers a steady amount of the raw ingredient your body needs to naturally boost NAD+ levels, helping you maintain critical elements of your health.
A well-chosen NMN supplement – one with high standards to testing, quality and scientific rigor – can go a long way to helping you experience your best health.
Why can’t NAD+ be taken as a supplement?
How does NMN support health?
Research indicates that stabilizing NAD+ levels is a promising strategy to improving cardiac function4, and may be linked to beneficial impacts on heart conditions5.
This is important because after age 30 you begin to lose around 3% to 8% of your muscle mass per decade. The rate of decline accelerates after you hit age 608. Less muscle means greater weakness and less mobility, reduced strength and exercise capacity, and increased risk of falls and fractures later in life.
The cellular ‘respiration’ process of turning nutrients into energy using NAD+ is the foundation of a healthy metabolism. In other words, NAD+ is the beginning of every energy-driven process that maintains health in your body.
Inflammation and immunity
Multiple studies have demonstrated that regulating NAD+ levels could be an effective strategy to control inflammaging. It has also been shown to help regulate diseases driven by chronic inflammation, such as neurodegenerative diseases and some cancers9,10,11
As you get older, particularly from middle age onwards, changes can start to occur within the brain that may trigger a gradual decline in mental capabilities. This is known as age-related cognitive decline, and it typically results in people becoming more forgetful and less mentally sharp. In severe instances, it can lead to dementia. By supporting metabolic processes in your brain NAD+ can support vital aspects of robust cognitive health12.
Treatment with NMN has been shown to substantially improve insulin sensitivity in pre-diabetic humans13. It has also been shown to reduce insulin sensitivity in subjects with age-related diabetes14,15. These results highlight NMN as an effective path for correcting declines in the way your body responds to insulin as you get older.
NAD+ is essential to DNA repair. The proteins in charge of the process use NAD+ as fuel to perform their vital functions16. When NAD+ is plentiful, it can also prevent the action of some proteins that meddle with your body’s ability to mend damaged DNA17. If NAD+ is not present in cells to stop this harmful interaction or to fuel repair, DNA breaks are not fixed. This can lead to cellular damage which drives the aging process itself.
A properly functioning 24-hour body cycle is important because misaligned circadian rhythms lead to sleep deprivation, which in turn can have profound consequences on your physical and mental health.
The future of NMN
Thanks to its role in boosting NAD+, NMN’s potential to promote bodywide health, recharge energy, support healthy aging, spark vitality, balance immunity, support vital organ and system function, and nurture better sleep has made it a vital part of the daily health routines of people seeking better health, for life.
Elevant NMN-C® – a new standard of NMN supplement
- Breakthrough NMN-C®: scientifically formulated to nourish cells and engineered to optimize energy and support healthy aging
- Created in collaboration with some of the world’s leading cellular health experts
- Superior safety and quality standards provide the ultimate peace of mind
- Certified CGMP, with US FDA Self-GRAS status, every batch is tested for impurities and has undergone rigorous testing for tolerability and safety.
- Our extensive program of in-human clinical research places us at the cutting-edge of global NMN research
2. Schultz MB, Sinclair DA. Why NAD(+) Declines during Aging: It's Destroyed. Cell Metab. 2016;23(6):965-966
3. Chini CCS, Tarragó MG, Chini EN. NAD and the aging process: Role in life, death and everything in between. Mol Cell Endocrinol. 2017 Nov 5;455:62-74
4. Walker MA, Tian R. Raising NAD in Heart Failure: Time to Translate?. Circulation. 2018;137(21):2274-2277
5. Vignier N, Chatzifrangkeskou M, Morales Rodriguez B, et al. Rescue of biosynthesis of nicotinamide adenine dinucleotide protects the heart in cardiomyopathy caused by lamin A/C gene mutation. Hum Mol Genet. 2018 Nov 15;27(22):3870-3880
6. Romani M, Sorrentino V, Oh CM, et al. NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle. Cell Rep. 2021;34(3):108660
7. Ryu D, Zhang H, Ropelle ER, et al. NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med. 2016;8(361):361ra139
8. Volpi E, Nazemi R, Fujita S. Muscle tissue changes with aging. Curr Opin Clin Nutr Metab Care. 2004;7(4):405-410
9. Covarrubias AJ, Kale A, Perrone R, et al. Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nat Metab. 2020;2(11):1265-1283
10. Minhas PS, Liu L, Moon PK, et al. Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation. Nat Immunol. 2019;20(1):50-63
11. Elhassan YS, Kluckova K, Fletcher RS, et al. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell Reports. 2019;28(7):1717-1728.e6
12. Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem. 2006 Aug 4;281(31):21745-21754
13. Yoshino M, Yoshino J, Kayser BD, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. Published online April 22, 2021
14. Basu R, Breda E, Oberg AL, et al. Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance. Diabetes. 2003;52(7):1738-1748
15. Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536
16. Wilk, A., Hayat, F., Cunningham, R. et al. Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity. Sci Rep 10, 651 (2020)
17. Jun Li, Michael S. Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P. Hubbard, Alvin J. Y. Ling, Luis A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn, David A. Sinclair. A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. SCIENCE24 MAR 2017 : 1312-1317