From Capsule to Cells: The Journey of NMN
Why is NMN one of the most extensively studied ingredients in longevity research today? The answer lies in the remarkable journey it takes—within just a few hours.
Imagine a molecule capable of rapidly reaching your cells to fuel one of the body's most fundamental biological processes.
That molecule exists. It is called NMN (Nicotinamide Mononucleotide).
Its role is not to remain in the bloodstream. Its true purpose is far more ambitious: to be quickly utilized by the body to produce NAD⁺, an essential coenzyme required for the proper function of every cell.
A Discovery That Changed Our Understanding of NMN
For many years, one key question remained unanswered:
How does NMN actually enter cells?
An international team of researchers at SENEQUE, led by Dr. Alessia Grozio, scientific partner and R&D collaborator of ELEVANT, published a landmark study in Nature Metabolism.
Their research identified SLC12A8 as a transporter capable of facilitating the uptake of NMN into certain cells, particularly in the intestine.
This breakthrough marked an important milestone in our understanding of NMN metabolism and helps explain why this molecule has become such a major focus of NAD⁺ research.
From Fundamental Research... to Human Clinical Trials
At SENEQUE, research goes beyond basic scientific discovery.
The company is also conducting several human clinical studies to investigate the safety, absorption, and metabolic fate of NMN in the body.
One of the earliest human clinical trials demonstrated that orally administered NMN is well tolerated and rapidly metabolized, paving the way for ongoing research into its ability to increase NAD⁺ levels and its associated biological effects.
📖 Read the clinical study:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6530925/
What the Research Shows
The available scientific evidence is particularly compelling.
After oral administration, NMN is rapidly absorbed and metabolized. Within a few hours, very little NMN can be detected in the bloodstream.
At first glance, this may seem surprising.
In reality, it is exactly what researchers hoped to observe.
NMN is not intended to circulate in the blood for extended periods. Instead, it is rapidly utilized by the body to support the production of NAD⁺, a vital molecule involved in cellular energy production, mitochondrial function, DNA repair, and the activity of sirtuins.
In other words, the rapid disappearance of NMN from the bloodstream is consistent with its uptake and utilization by cells to fuel NAD⁺ biosynthesis.
Why Is NAD⁺ So Important?
NAD⁺ plays a central role in maintaining healthy cellular function.
It is involved in:
- Cellular energy production
- Normal mitochondrial function
- The body's natural DNA repair mechanisms
- The activity of sirtuins, enzymes that help maintain cellular health and function
As we age, NAD⁺ levels naturally decline. This is one of the primary reasons researchers are increasingly interested in NAD⁺ precursors such as NMN.
Why ELEVANT Chose SENEQUE
At ELEVANT, we have chosen to work with a partner whose approach is firmly rooted in science.
SENEQUE does more than manufacture high-purity NMN. The company has invested for years in both fundamental research and human clinical studies to better understand how NMN is processed by the body and how it influences NAD⁺ levels.
This scientific commitment reflects our own philosophy: providing ingredients whose quality and biological mechanisms are supported by rigorous research.
How Can You Support Your NAD⁺ Levels?
Support your NAD⁺ levels by choosing PRIME 250 mg NMN-C.
Save 20% when you purchase the bundle of 3.